Restless Leg Syndrome

Restless leg syndrome (RLS) is a sensory neurological disorder where someone feels an uncomfortable sensation in their legs and experiences an uncontrollable urge to move them. It commonly occurs while at rest, before and/or during sleep and may become worse over time. Unfortunately, moving the legs only provides relief for a short time.

“Previously reported prevalence rates of RLS in migraine patients have ranged from 8.7 % to 39.0 %, with no significant differences between migraineurs with aura (MAs) and migraineurs without aura (MOs)”¹

Both restless leg syndrome and migraine are more common in women. A genetic study found an association between the Meis Homeobox 1 gene and increased risk of restless leg syndrome in those who have migraine, specifically migraine with aura.¹