Working to improve the lives of people with migraine

Research Funded by AMD in 2021

William Renthal, MD, PhD

Characterization of Migraine Characteristics and Treatment Response Using Semantic Learning


William Renthal, MD, PhD

Director of Headache Research, Assistant Professor of Neurology, Brigham and Women’s Hospital and Harvard Medical School

This project will develop a program that will allow researchers to rapidly scan through thousands of medical records to identify the various forms of migraine and how they respond to treatments in order to help physicians personalize migraine treatment.

Understanding the Association Between Sleep Apnea and Migraine


Eric Gruenthal, PhD

Sleep Medicine Fellow, Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine

Collaborators and Advisors:

Carl Saab, PhD - Director, Pain Science Technology and Research Lab, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine

Reena Mehra, MD, MS - Staff Physician and Professor of Medicine of the Cleveland Clinic Lerner College of Medicine

This project aims to investigate if sleep apnea and migraine are associated conditions and address whether treating sleep apnea will improve migraine frequency and symptoms. 

Gruenthal Photo


The Association of Migraine Disorders is led by a dynamic committee of leading researchers and medical professionals from around the world.

What is Migraine?

Migraine is not just a headache, it's a complex neurological disease that impacts more than 1 billion people worldwide. In this medical animation by Nucleus Medical Media, made in collaboration with AMD, you will learn possible causes of this disease and what happens in the brain during an attack.

This video is sponsored in part by Amgen/Novartis, and Abbvie.

Migraine Resource Kit for Health Care Providers

Migraine disease is a leading cause of disability in the US and impacts approximately 40M Americans, half of which are undiagnosed. It’s imperative for clinicians to stay updated about a disease that impacts one in nine patients.

The Association of Migraine Disorders is helping equip health care providers with information on how to diagnose and treat migraine patients through the Migraine Resource Kit. Resources include an online CME course and FREE printed materials such as patient brochures (English & Spanish), an exam room poster, medication dosing aids, treatment guides and migraine trackers.

*Only practicing healthcare providers are eligible to submit an order

Copy of Migraine Kit Instagram Post (1)
Spotlight on Migraine® Podcast

Spotlight on Migraine® is a podcast that explores the mysteries of migraine from many perspectives: patients, advocates, caregivers, health professionals and researchers.

Migraine Minute News Update is a series that gives you the latest in migraine research, education, and awareness once a week and in under 2 minutes.


The percent of people with migraine who have yet to be diagnosed.


The percent of people with migraine who have a family history with migraine.


The percent of people with migraine who face difficulties or discrimination at work because of their condition.

first 10 comorbidities (29)

The Link Between Migraine and Anxiety

Written by: Kylie Petrarca, RN, BSN Medically Reviewed by: Vera Gibb, DNP, APRN, FNP-C, AQH, CCTP Edited by: Melissa Calise What is Generalized Anxiety...
first 10 comorbidities (26)

Migraine and Post Traumatic Stress Disorder

Written by: Kylie Petrarca, RN, BSN Medically Reviewed by: Dr. Gretchen Tietjen Edited by: Melissa Calise What is Post Traumatic Stress Disorder? Post-traumatic stress...
first 10 comorbidities (20)

The Relationship Between Migraine and Trigeminal Neuralgia

Written by: Kylie Petrarca, RN, BSN Medically Reviewed by: Dr. Steven Bender Edited by: Leigh Serth What is the Trigeminal Nerve? The trigeminal nerve...

Free Online CME Course

A Migraine Toolbox

A Practical Approach to Diagnosis and Treatment

The Migraine Toolbox is a free, comprehensive “how-to” course in managing migraine. It covers the diagnosis and treatment of this disease. It includes downloadable practical tools – including questionnaires, medication guidelines for clinicians, a patient brochure, and other resources. Those with migraine have many symptoms and therefore are seen by a wide range of medical professionals. This educational program will enable primary care physicians, nurses, pharmacists, gastroenterologists, and other non-headache specialists to care for these patients.