Migraine Research Initiative

Accelerating Migraine Research

Mission

The Association Of Migraine Disorders Is devoted to accelerating neuroscience research that will advance the understanding of migraine disease, ultimately improving the lives of those living with the disease.

Goals

Enhance Collaboration: Foster collaborative and translational work between preclinical and clinical researchers.

Expand the Research Community: Build a diverse network of migraine researchers by connecting professionals from various specialties and supporting early-career scientists.

Prioritize Underexplored Research: Invest in research areas that are often overlooked, including a focus on topics especially pertinent to otolaryngologists.

Programs

MSC - Informational Slide for Editorial Board (1080 × 800 px) (1080 × 1080 px)

Migraine Science Collaborative

The Migraine Science Collaborative is a non-profit news website and information resource hub for the global community of migraine and headache basic scientists, clinical researchers, and clinicians. MSC produces original research news and opinion pieces, literature recaps, data visualizations, podcasts and webinars, and provides professional resources including grant opportunities, job postings, and event listings.

 

MSC is geared primarily to professionals working in any area of migraine research and/or care. MSC welcomes members at all career stages, including undergraduate students, graduate students, and postdocs, as well as investigators at more advanced career levels working in academia, government, companies, and other settings. Membership is free.

Headache, Ear, Auditory, Dizziness, Sinus (HEADS) Registry

The Association of Migraine Disorders has established the Headache, Ear, Auditory, Dizziness, Sinus (HEADS) Registry in 2023. It is a comprehensive registry that aims to gather critical data and insights from people about their experience with various head and neck symptoms, as well as their treatment journeys.

The HEADS Registry captures information about people (with or without migraine) who have sinus, vestibular, and auditory symptoms. Through an online survey, participants are asked about their symptoms, current and previous medications as well as information about their quality of life. The information will be used to improve the care and treatment of people living with these symptoms.

We invite providers to recruit their patients with dizziness, tinnitus, hearing problems, neck pain, TMD pain, sinus symptoms, or other otolaryngologic complaints.  

Access to this data is available to clinical and basic researchers, pending approval by the registry steering committee. 

HEADS research pg image

AMD’s research initiatives are led by our Research Advisory Committee (RAC), consisting of leaders in migraine and pain research. The RAC identifies knowledge gaps in migraine to influence future research projects and provides oversight for our grant program.

Research Advisory Committee

KC Brennan, MD, PhD

KC Brennan, MD, PhD

University of Utah

Basic mechanisms of migraine and post-traumatic headache

Larry Charleston IV, MD, MSc

Larry Charleston IV, MD, MSc

University of Michigan

Headache Disorders

Paul Durham, PhD

Paul Durham, PhD

Missouri State University

Cellular and molecular mechanisms, epigenetics

Gregory Dussor, PhD

Gregory Dussor, PhD

University of Texas at Dallas

Pathological mechanisms and therapeutic targets for migraine headache.

Georgia Hodes, PhD

Georgia Hodes, PhD

Virginia Polytechnic Institute and State University

Sex differences in the peripheral and central immune system 

Dan Levy, PhD

Dan Levy, PhD

Beth Israel Deaconess Medical Centre & Harvard Medical School

Research Focus: Intracranial meninges and its trigeminal sensory innervation

David Jang

David Jang, MD

Duke University

Research Focus: Otolaryngology

Felicia Jefferson, PhD

Felicia Jefferson, PhD

Fort Valley State University

Research Focus: Sleep science and minority research career development

Deena Kuruvilla, MD

Deena Kuruvilla, MD

Yale School of Medicine

Research Focus: Headache disorders

William Renthal, MD, PhD

William Renthal, MD, PhD

Brigham and Women’s Hospital & Harvard Medical School

Research Focus: Human genetics related to migraine pathophysiology

Jelena Pavlović, MD, Ph

Jelena Pavlović, MD, PhD

Albert Einstein College of Medicine

Research Focus: Hormonal regulation of migraine

Nasim Maleki, PhD

Nasim Maleki, PhD

Massachusetts General Hospital

Research Focus: Sex-related contributions to migraine disease

Angela O'Neal, MD

Angela O'Neal, MD

Brigham and Women's Hospital

Research Focus: Women’s neurology

Michael Teixido, M.D.

Michael Teixido, MD

Thomas Jefferson University

Research Focus: Otolaryngology and migraine

Amynah Pradhan, PhD

Amynah Pradhan, PhD

University of Illinois

Research Focus: Translationally significant animal models of headache 

Gretchen Tietjen, MD

Gretchen Tietjen, MD

University of Toledo

Research Focus: Migraine, stroke, early life stress, vascular biology

Stephen Silberstein, MD, FACP, FAAN, FAHS

Stephen Silberstein, MD, FACP, FAAN, FAHS

Thomas Jefferson University

Research Focus: Headache disorders

RizkHabib-ENT

Habib Rizk, MD

Medical University of South Carolina

Research Focus: Vestibular and balance disorders

Carl Saab, PhD

Carl Saab, PhD

Cleveland Clinic

Research Focus: Translational research in chronic pain

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Chia-Chun Chiang, MD

Mayo Clinic

Research Focus: Artificial Intelligence in Headache Medicine

week of april 4

Elizabeth Seng, PhD

Yeshiva University

Research Focus: Behavioral Management of Headache Disorders

racial disparities

Ioana Medrea, MD, MSc, FRCPC(C)

SUNY Upstate

Research focus: Cluster headache and migraine disorders

Grant Program

One of our goals is to invigorate the study of migraine disease. AMD is pursuing several different methods to achieve this goal.  

We are working to support preclinical and clinical researchers early in their careers by financing Travel Grants and creating an opportunity to highlight their research projects at our annual Emerging Science Contest.  We also offer grants specifically to Otolaryngology Residents.  This is consistent with our efforts to expand the reach of migraine research into different disciplines, whether preclinical research laboratories or medical specialties.  AMD has a particular focus on engaging the specialty of otolaryngology in migraine research. AMD also provides seed grants for novel research ideas.  

Finally, AMD works with the Brown Migraine Center and Brown University's Carney Institute for Brain Science to develop interdisciplinary research. 

Resident Research Grant

The program offers one-year grants to any otolaryngology residents conducting a research project that is related to improving our understanding of migraine variants. The Resident Research Grants are available at any time.

We are using CORE to administer our Resident Research Grants. You can follow this link to see more info and to apply for a grant.

Research Funded By AMD

2024 - Principal Investigator: Tasha Nasrollahi, MD, University of California Irvine
Project: Nortriptyline-Topiramate vs. Lifestyle Modifications for Vestibular Migraine
CORE Grant Amount: $10,000 two-year grant

 

2024 - Principal Investigator: Francescantonio Cammarota, MD, University of Pavia, Dept. of Brain and Behavioral Sciences
Project: Neurophysiological and Biomolecular Effects of Atogepant in Episodic Migraine
CORE Grant Amount: $10,000


2023 - Principal Investigator: Amynah Pradhan, PhD, Washington University
Project: Development of a Behavioral Screening Platform for Novel Headache Therapeutics
Grant Amount: $50,000 two-year grant

 

2023 - Principal Investigator: Gregory Dussor, PhD The University of Texas Foundation for the benefit of The University of Texas at Dallas$49,100 two-year grant
Project: Development of a Behavioral Screening Platform for Novel Headache Therapeutics
Grant Amount: $49,100 two-year grant

 

2023 - Principal Investigator: Jianguo Gu, PhD, The Board of Trustees of the University of Alabama for the University of Alabama at Birmingham
Project: Characterization of trigeminal nerves that innervate the sinus in rodents.
Grant Amount: $115,000

 

2023 - Principal Investigator: Nasim Maleki, PhD, Massachusetts General Hospital
Project: Identifying immune, hormonal, and metabolic signatures across Lifespan in Women
Grant Amount: $62,698

 

2023 - Principal Investigator: Khodayar, UCI Department of Otolaryngology
Project: Otologic Manifestations of Long-COVID and their Management as Migraine PhenomenaLifespan in Women
CORE Grant Amount: $10,000

 

2023 - Principal Investigator: Emilia Iannilli, PhD, Institut für Klinischer Psychologie
Project: Central Pathway of Chronic Migraine (CM) and Relation to Chronic Midfacial Symptomatology (CMS)
Grant Amount: $114,791


2022 - Principal Investigator: Omid Moshtaghi, MD, The Regents of the University of California
Project: Migraine in Patients with Vestibular Schwannoma and the Impact of Treatmen
CORE Grant Amont:  $9,067


2021 - Principal Investigator: William Renthal, M.D., PhD, Brigham and Women’s Hospital and Harvard Medical School
Project: Characterization of migraine characteristics and treatment response using semantic learning
Grant Amount: $192,182

 

2021 - Principal Investigator: Reena Mehra MD, MS, FCCP, FAASM, FAHA, ATSF, Cleveland Clinic Foundation
Project: Sleep Disordered Breathing and Migraine
Grant Amount: $35,00


2020 - Principal Investigator: Janet Choi, USC
Project: Clinical Utility of Multifrequency VEMP in Vestibular Migraine Diagnosis
CORE Grant Amount: $10,000


2019 - Principal Investigator: Lyn Griffiths Ph.D., Queensland University of Technology
Project: Genetic analysis of mitochondrial DNA and nuclear-encoded mitochondrial genes in familial migraine with aura
MRF Grant Amount:  $48,000

 

2019 - Principal Investigator: Eric Formeister, UC SF
Project: Mindfulness-Based Stress Reduction for the Treatment of Vestibular Migraine
CORE Grant Amount:  $10,000


2017 - Principal Investigator: Suzanne Bertisch, Beth Israel Deaconess Medical Center to Brigham & Women’s Hospital
Project: Shedding Light on Migraine: Exploring Novel Light Metrics as a Trigger of Migraine
MRF Grant Amount: $50,000
UPDATE: Completed in 2020 https://migraineresearchfoundation.org/researchers/suzanne-bertisch/

 

2017 - Principal Investigator: Hossein Mahboubi, UC Irvine
Project: Randomized clinical trial of nortriptyline in treatment of vestibular migraine
CORE Grant Amount: $5,500
UPDATE: Research ended due to lack of participants


2016 - Principal Investigator: Clas Linnman, Boston Children’s Hospital
Project: Microglial proliferation in women with menstrual migraines
MRF Grant Amount: $50,000


2015 - Principal Investigator: Patricia Vall, Pozo-Rosich, d’Hebron University Hospital
Project: microMIG: searching for new biomarkers in migraine using microRNA expression profile analysis
MRF Grant Amount: $50,000


2014 - Principal Investigator: David Witsell, MD, MHS, Duke University
Project: Patterns of Migraine Disease in Otolaryngology: A CHEER Network Study
Grant Amount: $190,000

 

2014 - Principal Investigator: Robert Shapiro, UVM
Project: Gastroparesis in Monogenic Migraine Mouse Models
MRF Grant Amount: $50,000

 

2014 - Principal Investigator: Lyn Griffiths Ph.D., Queensland University of Technology
Project: Use of Next Generation Sequencing Technology to Identify Novel Hemiplegic Migraine and Migraine Related Mutations.
MRF Grant Amount: $50,000

 

2014 - Principal Investigator: Maggie Waung, University of California San Francisco
Project: The Role of Metabotropic Glutamate Receptors in Migraine
Grant Amount: $50,000

 

2014 - Principal Investigator: Anthony Mikulec, MD, Saint Louis University
Project: A prospective randomized cross-over trial of nortriptyline and topiramate in the initial treatment of vestibular migraine
Grant Amount: $50,000

 

We invite providers to recruit their patients with dizziness, tinnitus, hearing problems, neck pain, TMD pain, sinus symptoms, or other otolaryngologic complaints.
Access to this data is available to clinical and basic researchers, pending approval by the registry steering committee.

Thank you to our sponsor!