Migraine and Post Traumatic Stress Disorder

Migraine and Post Traumatic Stress Disorder

Written by: Kylie Petrarca, RN, BSN

Medically Reviewed by: Dr. Gretchen Tietjen

Edited by: Melissa Calise

What is Post Traumatic Stress Disorder?

Post-traumatic stress disorder (PTSD) is a mental health condition that occurs from experiencing a traumatic event and leads to symptoms such as persistent flashbacks or nightmares of the event (intrusion), a wish to avoid thinking or talking about the event (avoidance), feelings of blame, guilt, or detachment (negative alterations in emotions/mood), and feeling on guard or being easily frightened or startled (alterations in arousal and reactivity).1 The most common traumatic events that precipitate PTSD are witnessing sudden and/or violent death, or experiencing natural disasters, physical and/or sexual abuse, combat events and car accidents. 

During a traumatic life event (TLE), the fight or flight response is activated which increases heart rate, respiratory rate and stress hormones. These symptoms may appear for a few hours to a couple weeks after the event. For others, symptoms may last longer and a PTSD diagnosis should be considered when they persist for more than one month. 

People who develop PTSD may have a genetic vulnerability to this condition as well as underlying physiological differences when exposed to trauma. PTSD is often referred to as a “hidden wound” due to the silent suffering a person experiences, which aligns with the experiences of many people living with migraine. PTSD affects approximately 5-8% of the population at some point in their lifetime, affecting women about as twice as frequently as men.2

What is the Relationship Between Migraine and PTSD? 

The underlying relationship between migraine and PTSD is not understood. However, one hypothesis is that there may be a dysfunction between the autonomic nervous system and the hypothalamic-pituitary-adrenal axis.2 The hypothalamic-pituitary-adrenal axis is responsible for the stress response system and regulates the autonomic nervous system. The autonomic nervous system has two divisions: the parasympathetic nervous system (rest and digest) and the sympathetic nervous system (fight or flight). When exposed to stressful stimuli, the sympathetic nervous system is activated and results in an increased heart rate and respiratory rate, dilated pupils, tremors, etc.  

PTSD is more prevalent in those living with migraine than in the general population (14–25% vs 1–12%).Additionally, PTSD and migraine coexist 2-3 times more in women than in men, however, several studies suggest that odds of PTSD in men with migraine are two-fold higher than in women.1,4

Research demonstrates abnormal lab levels in those with migraine, PTSD and both conditions:2

Migraine PTSD Migraine and PTSD
Elevated cortisol levels. Elevated cortisol in those who experienced a traumatic life event, followed by low levels once PTSD developed. Lower serotonin and norepinephrine levels.

Currently, the evidence is unclear if migraine begins first and predisposes someone to PTSD or if PTSD makes someone more likely to have migraine disease. A study found that 69% of people with both episodic migraine and PTSD had PTSD-related symptoms prior to the onset of headaches, suggesting PTSD could trigger the onset of migraine.2

Military Personnel, Migraine and PTSD 

Military veterans are at high risk of developing PTSD and traumatic brain injury due to their profession. PTSD affects 18% of combat veterans and may be underestimated due to mental health stigma.5 In a veteran-based study, 50% of those with migraine also met the criteria for PTSD.2 Migraine is considered a service-connected disability if the onset of migraine began during the time of service. Military personnel can be eligible for a secondary service connection when a condition that occurred during the time of service caused a new condition which led to disability (ex. PTSD caused migraine). Overall, migraine is extremely prevalent among veterans with PTSD. Those diagnosed with migraine should be screened for comorbid PTSD due to the overlapping pathophysiological mechanisms and shared treatment modalities. 

Recommended Treatments for PTSD and Migraine 

Treatments for migraine and PTSD are similar with psychotherapy, medications and self-care as common modalities. Behavioral based therapy such as Acceptance and Commitment Therapy, Cognitive Behavioral Therapy (CBT) and Mindful Based Stress Reduction (MBSR) are often used as part of a treatment plan, often with medication therapy, to learn coping mechanisms for both conditions and and pain management for migraine. Cognitive behavioral therapy (CBT) was found to improve the disability of patients with migraine and comorbid PTSD.3 Selective serotonin reuptake inhibitors (SSRIs) such as sertraline and paroxetine are FDA approved for PTSD but have not proven effective for the treatment of migraine. On the other hand, serotonin norepinephrine reuptake inhibitors (venlafaxine) and tricyclic antidepressants (amitriptyline) have been used off-label for the treatment of migraine and PTSD. Deep breathing, journaling and exercise are also recommended for both conditions. In January 2022, the FDA granted gammaCore (non-invasive vagus nerve stimulation) “breakthrough device designation” for the treatment of PTSD. GammaCore is also approved for the acute and preventive treatment of migraine.

Depression, PTSD and Migraine 

Both migraine and PTSD share other common comorbidities such as depression. A study found that women with PTSD were 4.1 times more likely to develop depression than those without PTSD, while men with PTSD were found to be 6.9 times more likely to develop depression than those without PTSD.The study also found that those with both major depression and PTSD had a higher incidence of chronic daily headache than episodic migraine.4

A Note To Patients and Providers

For patients, it is important to tell your health care provider if you have experienced a traumatic life event and have the symptoms of PTSD and/or migraine. This can assist the provider in creating an individualized treatment plan, hopefully leading to better outcomes. For physicians, screening for anxiety and/or depression is not sufficient for a PTSD diagnosis. PTSD may be screened by utilizing the PTSD checklist or the Primary Care PTSD Screen for DSM-5 (PC-PTSD-5).6 Those screening positive require further assessment, and Clinician-Administered PTSD Scale for DSM-5 (CAPS-5), a 30-item structured interview, is considered the gold standard. Veterans are extremely vulnerable to both PTSD and migraine and additional evaluation should be given.


  1. National Center for PTSD
  2. Give an hour
  3. PTSD Coach App


  1. Dr. Gretchen Tietjen’s presentation on PTSD and Migraine at the 2022 Scottsdale Headache Symposium
  2. Peterlin BL, Nijjar SS, Tietjen GE. Post-traumatic stress disorder and migraine: epidemiology, sex differences, and potential mechanisms. Headache. 2011 Jun;51(6):860-8. doi: 10.1111/j.1526-4610.2011.01907.x. Epub 2011 May 17. PMID: 21592096; PMCID: PMC3974501.
  3. Minen MT, et al. J Neurol Neurosurg Psychiatry 2016;87:741–749. doi:10.1136/jnnp-2015-312233
  4. B. Lee Peterlin DO, Gretchen E. Tietjen MD, Jan L. Brandes MD, Susan M. Rubin MD, Ellen Drexler MD, Jeffrey R. Lidicker MSc, Sarah Meng DO
  5. Lawson, Nicole R. MS, PA-C. Posttraumatic stress disorder in combat veterans. JAAPA: May 2014 – Volume 27 – Issue 5 – p 18-22 doi: 10.1097/01.JAA.0000446228.62683.52
  6. Prins, A., Bovin, M. J., Kimerling, R., et al., (2015). Primary Care PTSD Screen for DSM-5 (PC-PTSD-5) [Measurement instrument]. Available from https://www.ptsd.va.gov

*The contents of this blog are intended for general informational purposes only and do not constitute professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. The writer does not recommend or endorse any specific course of treatment, products, procedures, opinions, or other information that may be mentioned. Reliance on any information provided by this content is solely at your own risk.

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