Sinusitis is an inflammation of the tissue lining the sinuses. Acute sinusitis is often caused by common cold or allergies and may lead to a bacterial sinus infection. Sinusitis most commonly lasts 2-4 weeks. Chronic sinusitis can occur from a polyp or infection and lasts three months or longer.

A study found that greater than 80% of patients presenting with sinusitis met the criteria for migraine disease.1

It is hypothesized that the activation of the trigeminal-autonomic reflex causes sinus-like symptoms: mid-facial pain, stuffy nose, nasal drainage and loss of smell. It is unclear whether or not sinusitis and migraine are truly comorbidities or migraine is manifesting with symptoms that are typically associated with sinusitis.