Multiple sclerosis is an autoimmune disease that affects the central nervous system. The immune system attacks the protective coating of nerves (known as the myelin sheath). The demyelination leads to nerve damage causing profound neurological symptoms.
A study that assessed the relationship between migraine and MS found that among 204 MS patients, the relative frequency of migraine was three times higher than in the non-MS population controls both for men and women.1
The study also found that pain related conditions such as trigeminal neuralgia, facial pain, TMD joint pain and restless leg syndrome were 2-5 times higher in those who had MS and migraine compared to those without.1 All of the pain related conditions listed are also comorbid with migraine disease.