Depression is a mood disorder that results in profound feelings of sadness, hopelessness and loss of self worth. It often causes loss of interest and pleasure in activities, fatigue and changes in sleep. In order to consider a diagnosis of depression, symptoms must persist for two weeks or greater. A healthcare provider should be notified about any mood changes. Depression and migraine have a bidirectional relationship and share common pathophysiology, treatments and relations to other comorbidities.

“Three different studies found that migraineurs are over 2.5 times more likely to suffer from depression compared with non-migraineurs.”1