Complex Regional Pain Syndrome (CRPS) is a rare neuroinflammatory disorder that causes extreme pain in an arm or leg after an injury or nerve trauma. It can be acute (less than six months) or chronic (greater than six months). Like migraine, CRPS is a disabling condition, more common among women and does not have a definitive diagnostic test. Migraine and CRPS also share many psychological comorbidities such as anxiety, depression and bipolar disorder.
Peterlin et.al found that “those with CRPS were 3.6 times more likely to have migraine and nearly twice as likely to have chronic daily headache as the general population.”1