NSAIDs, such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Anaprox) can effectively control migraine pain in many conditions.
How they work
They suppress the pain and inflammatory phase of a migraine attack. Normally during migraine attacks, prostaglandins are released and they sensitize pain sensors. NSAIDs block the synthesis of prostaglandins.
NSAIDs block the enzyme cyclooxygenase (COX) from synthesizing prostaglandins, which cause pain and inflammation. NSAIDs may not only reduce pain transmissions through these nerves, but reduce the generation of further cortical spreading depressions.